Christina B. Young
INSTRUCTOR
DEPARTMENT OF NEUROLOGY & NEUROLOGICAL SCIENCES
STANFORD UNIVERSITY SCHOOL OF MEDICINE
CLINICAL PSYCHOLOGY PH.D.
STATISTICS M.S.
Education
2020 – 2022 Postdoctoral Fellow, Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Palo Alto CA
2018 – 2020 Postdoctoral Fellow, Neuropsychology Clinic, Stanford Health Care, Stanford CA
2018 – 2020 Postdoctoral Fellow, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto CA
2017 – 2018 Clinical Science Internship, Department of Psychiatry, University of Illinois at Chicago (UIC) College of Medicine, Chicago IL
2014 – 2018 Ph.D., Clinical Psychology, Northwestern University, Evanston, IL
2017 – 2018 Pre-doctoral Clinical Psychology Internship, Department of Psychiatry, University of Illinois at Chicago (UIC) College of Medicine, Chicago IL
2011 – 2017 M.S., Statistics, Northwestern University, Evanston, IL
2014 – 2015 Visiting Fellow Funded by the National Science Foundation (NSF) and Netherlands Organisation for Scientific Research (NWO), Donders Institute for Brain, Cognition and Behaviour; Department of Psychiatry, Radboud University Medical Center
2011 – 2014 M.S., Clinical Psychology, Northwestern University, Evanston, IL
2006 – 2009 B.S. Summa Cum Laude, Psychology with Mathematics Minor University of California, San Diego (UCSD), La Jolla CA
Grants
06/01/2023 - 05/32/2025 Funder: New Vision Research, Role: PI.
09/01/2022 - 08/31/2027 Funder: NIH NIA K99/R00, Role: PI.
04/01/2022 - 03/31/2024 Funder: Stanford ADRC Executive Committee and NIH NIA, Role: Co-Investigator.
09/01/2021 - 08/31/2024 Funder: Alzheimer's Association Research Fellowship to Promote Diversity (AARF-D), Role: PI.
09/30/2021 - 05/31/2023 Funder: NIH NIA R21, Role: Co-Investigator.
2015 - 2016 Funder: NIH NINDS Training Program in the Neuroscience of Human Cognition, Role: Trainee.
2014 - 2015 Funder: NSF and Netherlands Organisation for Scientific Research (NWO), Role: PI.
2012 - 2015 Funder: NSF Graduate Research Fellowship Program, Role: PI.
2008 - 2009 Funder: John A. Majda, M. D. Foundation, Role: PI.
Publications
Computerized cognitive practice effects in relation to amyloid and tau in preclinical
Alzheimer's disease: Results from a multi-site cohort.
Alzheimer's & Dementia: Diagnosis, Assessment, & Disease Monitoring, 15(1), e12414.
PubMed Link
Young, C. B., Johns, E., Kennedy, G., Belloy, M. E., Insel, P. S., Greicius, M. D., Sperling, R. A., Johnson, K. A., Poston, K. L., & Mormino, E. C. for the Alzheimer's Disease Neuroimaging Iniatitive & the A4 Study Team (2023)
APOE effects on regional tau in preclinical Alzheimer's disease.
Molecular Neurodegeneration, 18(1).
PubMed Link
Insel, P. S., Young, C. B., Aisen, P. S., Johnson, K. A., Sperling, R. A., Mormino, E. C., & Donohue, M. C. (2023)
Tau positron emission tomography in preclinical Alzheimer's disease.
Brain, 146(2), 700-711.
PubMed Link
Su, H., Young, C. B., Zhuo, R. H., Xu, J., Xiong, B., Zhou, Z., Wang, J., Hao, L., Zhi, Y., Chen, G., & Qin, S. (2023)
Atypical child-parent neural synchrony is linked to negative family emotional climate
and
children's psychopathological symptoms
PubMed Link
Wilson, E. N., Young, C. B., Benitez, J. R., Swarovski, M. S., Feinstein, I., Vandijck, M., Le Guen, Y., Kasireddy, N. M., Shahid, M., Corso, N. K., Wang, Q., Kennedy, G., Trelle, A. N., Lind, B., Channappa, D., Belnap, M., Ramirez, V., Skylar-Scott, I., Younes, K., Yutsis, M. V., Le Bastard, N., Quinn, J. F., van Dyck, C. H., Nairn, A., Fredericks, C. A., Tian, L., Kerchner, G. A., Montine, T. J., Sha, S. J., Davidzon, G., Henderson, V. W., Longo, F. M., Greicius, M. D., Wagner, A. D., Wyss-Coray, T., Poston, K. L., Mormino, E. C., & Andreasson, K. I. (2023)
Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer's
disease.
Alzheimer's Research & Therapy, 14(1).
PubMed Link
Young, C. B., Winer, J. R., Younes, K., Cody, K. A., Betthauser, T. J., Johnson, S. C., Schultz, A., Sperling, R. A., Greicius, M. D., Cobos, I., Poston, K. L., & Mormino, E. C. for the Alzheimer's Disease Neuroimaging Initiative and the Harvard Aging Brain Study (2022)
Divergent cortical tau positron emission tomography patterns among patients with
preclinical Alzheimer disease.
JAMA Neurology, 79(6), 592-603.
PubMed
Link
AlzForum Coverage 1
AlzForum Coverage 2
Young, C. B. & Mormino, E. C. (2022)
Prevalence rates of amyloid positivity - Updates and relevance.
JAMA Neurology, 79(3), 225-227.
PubMed Link
Cai, W., Young, C. B., Yuan, R., Lee, B., Ryman, S., Kim, J., Yang, L., Henderson, V. W., Poston, K. L., & Menon, V. (2022)
Dopaminergic medication normalizes aberrant cognitive control circuit signaling in
Parkinson's disease.
Brain
PubMed Link
Damme, K. S. F., Alloy, L. B., Kelley, N. J., Carroll, A., Young, C. B., Chein, J., Ng, T. H., Titone, M. K., Bart, C. P., & Nusslock, R. (2022)
Bipolar spectrum disorders are associated with increased gray matter volume in the
medial
orbitofrontal cortex and nucleus accumbens.
JCPP Advances, e12068
Full-Text Link
Lee, B., Cai, W., Young, C. B., Yuan, R., Ryman, S., Kim, J., Santini, V., Henderson, V. W., Poston, K. L., & Menon, V. (2022)
Latent brain state dynamics and cognitive flexibility in older adults.
Progress in Neurobiology, 208:102180.
PubMed Link
Montaser-Kouhsari, Young, C. B., & Poston, K. L. (2022)
Neuroimaging approaches to cognition in Parkinson's disease.
Progress in Brain Research, 269(1), 257-286.
PubMed Link
Young, C. B., Landau, S. M., Harrison, T. M., Poston, K. L., & Mormino, E. C. (2021)
Influence of common reference regions on regional tau patterns in cross-sectional and
longitudinal [18F]-AV-1451 PET data.
Neuroimage, 243:118553.
PubMed Link
Bart, C. P., Nusslock, R., Ng, T. H., Titone, M. K., Carroll, A. L., Damme, K. S. F., Young, C. B., Armstrong, C. C., Chein, J. & Alloy, L. B. (2021)
Decreased reward-related brain function prospectively predicts increased substance use.
Journal of Abnormal Psychology, 130(8), 886-898.
PubMed Link
Sturchio, A., Dwivedi, A. K., Young, C. B., Malm, T., Marsili, L., Sharma, J. S., Mahajan, A., Hill, E. J., Andaloussi, S. E., Poston, K. L., Manfredsson, F. P., Schneider, L. S., Ezzat, K., & Espay, A. J. (2021)
High cerebrospinal amyloid-β 42 is associated with normal cognition in individuals with
brain amyloidosis.
EClinicalMedicine, 38:100988.
PubMed Link
Tian, T., Young, C. B., Zhu, Y., Xu, J., He, Y., Chen, M., Hao, L., Jiang, M., Qiu, J., Chen, X., & Qin, S. (2021)
Socioeconomic disparities affect children's amygdala-prefrontal circuitry via stress
hormone response.
Biological Psychiatry, 90(3), 173-181.
PubMed Link
Damme, K. S., Alloy, L. B., Young, C. B., Kelley, N. J., Chein, J., Ng, T. H., Titone, M. K., Black, C. L., & Nusslock, R. (2020)
Amygdala subnuclei volume in bipolar spectrum disorders: Insights from diffusion-based
subsegmentation and a high-risk design.
Human Brain Mapping.
PubMed Link
Kendall, A. D., Young, C. B., Bray, B. C., Emerson, E. M., Freels, S., & Donenberg, G. R. (2020)
Changes in externalizing and internalizing symptoms among African-American girls over 1
year following a mother-daughter sexual health intervention.
Journal of Consulting and Clinical Psychology, 88(6), 495-603.
PubMed Link
Gorka, S. M.*, Young, C. B.*, Klumpp, H., Kennedy, A. E., Francis, J., Ajilore, O., Langenecker, S. A., Shankman, S. A., Craske, M. G., Stein, M. B., & Phan, K. L. (2019)
Emotion-based brain mechanisms and predictors for SSRI and CBT treatment of anxiety and
depression: A randomized trial.
Neuropsychopharmacology, 44 (9), 1639-1648.
PubMed Link
* These authors contributed equally.
Young, C. B., Raz, G., Everaerd, D., Beckmann, C. F., Tendolkar, I., Hendler, T., Fernández, G., & Hermans, E. J. (2017)
Dynamic shifts in large-scale brain network balance as a function of arousal.
The Journal of Neuroscience, 3 (2), 281-290.
PubMed Link
Damme, K. S., Young, C. B., & Nusslock, R. (2017).
Elevated nucleus accumbens structural connectivity associated with proneness to
hypomania:
A reward hypersensitivity perspective.
Social Cognitive and Affective Neuroscience, 12 (6), 928-936.
PubMed Link
Young, C. B., Chen, T., Nusslock, R., Keller, J., Schatzberg, A. F., & Menon, V. (2016).
Anhedonia and general distress are associated with dissociable ventromedial prefrontal
cortex connectivity in major depressive disorder.
Translational Psychiatry, 6, e810.
PubMed Link
Young, C. B., & Nusslock, R. (2016).
Positive mood enhances reward-related neural activity.
Social Cognitive and Affective Neuroscience, 11, 934-944.
PubMed Link
Young, C. B., van Eijndhoven, P., Nusslock, R., Fernández, G., Schene, A., Beckmann, C. F., & Tendolkar, I. (2016).
Decreased hippocampal volume is related to white matter abnormalities in treatment-resistant depression. International Journal of Brain Disorders and Treatment, 2:012.
Young, C. B., Müller, B., & Tendolkar, I. (2016).
Imaging functional systems in depression. In Frodl, T. (Eds.). Systems Neuroscience in Depression. Elsevier Science.
Nusslock, R., Young, C. B., & Damme, K. (2014).
Elevated reward-related neural activation as a unique biological marker of bipolar
disorder: Assessment and treatment implications.
Behaviour Research and Therapy, 62, 74-87.
PubMed Link
Qin, S., Young, C. B., Duan, X., Chen, T. & Menon, V. (2014).
Amygdala subregional structure and intrinsic functional connectivity predicts individual
differences in anxiety during early childhood.
Biological Psychiatry, 75, 892–900.
PubMed Link
Rosenberg-Lee, M., Ashkenazi, S., Chen, T., Young, C. B., Geary, D., & Menon, V. (2014).
Brain hyper-connectivity and operation-specific deficits during arithmetic problem
solving
in children with developmental dyscalculia.
Developmental Science, 18, 351-372.
PubMed Link
Keller, J*. Young, C. B.*, Kelly, E., Prater, K., Levitin, D. J., & Menon, V. (2013).
Trait anhedonia is associated with reduced reactivity and connectivity of mesolimbic and
paralimbic reward pathways.
Journal of Psychiatric Research, 47, 1319–1328.
PubMed Link
* These authors contributed equally.
Nusslock, R., Young, C. B., & Pornpattananangkul, N., & Damme, K. (2013).
Neurophysiological and neuroimaging approaches to clinical psychology research. In R. Cautin & S. Lilienfield (Eds.), Encyclopedia of Clinical Psychology. New Jersey: Wiley-Blackwell.
Young, C. B., Wu, S., & Menon, V. (2012).
Neurodevelopmental basis of math anxiety.
Psychological Science, 23, 492–501.
PubMed Link
Cho, S., Metcalfe, A. W. S., Young, C. B., Ryali, S., Geary, D. C., & Menon, V. (2012).
Hippocampal-prefrontal engagement and dynamic causal interactions in the maturation of
children’s fact retrieval.
Journal of Cognitive Neuroscience, 24, 1849–1866.
PubMed Link
Fang, D. Z., Young, C. B., Golshan, S., Moutier, C., & Zisook, S. (2012).
Burnout in premedical undergraduate students.
Academic Psychiatry, 36, 11–16.
PubMed Link
Qin, S., Young, C. B., Supekar, K., Uddin, L. Q., & Menon, V. (2012).
Immature integration and segregation of emotion-related brain circuitry in young
children.
Proceedings of the National Academy of Sciences, 109, 7941–7946.
PubMed Link
Rosenberg-Lee, M., Chang, T. T., Young, C. B., Wu, S., & Menon, V. (2011).
Functional dissociations between four basic arithmetic operations in the human parietal
cortex: A cytoarchitectonic mapping study.
Neuropsychologia, 49, 2592–2608.
PubMed Link
Uddin, L. Q., Menon, V., Young, C. B., Ryali, S., Chen, T., Khouzam, A., Minshew, N. J., Hardan, A. Y. (2011).
Multivariate searchlight classification of structural magnetic resonance imaging in
children and adolescents with Autism.
Biological Psychiatry, 70, 833–841.
PubMed Link
Young, C. B., Fang, D. Z., & Zisook, S. (2010).
Depression in Asian-American and Caucasian undergraduate students.
Journal of Affective Disorders, 125, 379–382.
PubMed Link
Fang, D. Z., Young, C. B., Golshan, S., Fellows, I., Moutier, C., & Zisook, S. (2010).
Depression in premedical undergraduates: A cross-sectional survey.
The Primary Care Companion to the Journal of Clinical Psychiatry, 12.
PubMed Link
Awards & Honors
2023 New Vision Investigator Awardee as part of the Charleston Conference on Alzheimer's Disease (CCAD)
2022 Alzheimer's Association Award for Young Scientists
2022 Alzheimer's Association International Conference Fellowship Award
2022 Henry Newman Award for best paper relevant to clinical neurology, 73rd Annual Meeting for the San Francisco Neurological Society
2020 Rapid Research Presentation Award, 22nd Annual NINDS Udall Centers Meeting
2017 Nominee for the Florence Sales Best TA of the Year Award, Northwestern University.
2016 – 2017 Recipient of Walter Dill Scott Scholarship, Northwestern University.
2015 – 2016 Predoctoral Trainee in the Neuroscience of Human Cognition Training Program, National Institute of Health (NIH).
2014 Travel Award, Organization for Human Brain Mapping.
2009 Summa Cum Laude/Highest Distinction Honors, UCSD.
2009 Research Grant, John A. Majda, M.D. Foundation.
2008 – 2009 Faculty Mentor Program, UCSD.
2008 – 2009 Psychology Honors Program, UCSD.
2008 – 2009 Provost’s Honors, UCSD.
2007, 2009 Thurgood Marshall Scholar and Citizen Award, UCSD.
Clinical Experience
2018 – 2022 Clinical Postdoctoral Fellow, Stanford Neuropsychology Clinic, Stanford Health Care
2017 – 2018 Psychology Intern, Neuropsychology Clinic, UIC College of Medicine
2017 – 2018 Psychology Intern, Family Medicine Clinic, UIC College of Medicine
2017 – 2018 Psychology Intern, HIV/Health Prevention/Intervention Clinic, UIC College of Medicine
2016 – 2017 Psychology Extern, Systemic Therapy Practicum, The Family Institute at Northwestern University
2015 – 2017 Assessor, Symptom Dimensions of Threat- and Reward-Related Neurocircuitry (NIMH R01), Northwestern University
2015 – 2016 Psychology Extern, Dialectical Behavior Therapy Clinic, The Family Institute at Northwestern University
2013 – 2014 Psychology Extern, Depression Treatment Clinic, The Family Institute at Northwestern University
2013 – 2014 Psychology Extern, Anxiety Disorder Treatment Clinic, The Family Institute at Northwestern University
2012 – 2013 Psychology Extern, Diagnostic Interviewing Assessment Program, The Family Institute at Northwestern University